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VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Due to its increased acidity, VEGF 121 circulates more freely than other VEGF forms, which bind more tightly with vascular heparin sulfates. Recombinant Human VEGF 121 is a 28.4 kDa, disulfide-linked homodimeric protein consisting of two 121 amino acid polypeptide chains.

Protein/peptide name	VEGF 121
Protein synonyms	Folliculostellate cell-derived growth factor,Vascular Endothelial Growth Factor,VEGF-A,Glioma-derived endothelial cell mitogen
Protein/peptide type	Recombinant
Species	Human
Source	E. coli
Conjugation	Unconjugated
Gene ID	7422
Sequence	APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENCDKPR R
Animal-free	Y
Endotoxin level	low
Biological activity	Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 0.2-0.4 ng/ml.
Purity	98%
Formulation	Lyophilized
Molecular weight	28.4 kDa
Shipping temperature	Ambient
Molecular weight	28.4 kDa